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Jump to site search. You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page. Ethyl acetate reacts with two moles of phenylmagnesium bromide and thus by furnishing 1,1-diphenylethanol, a tertiary alcohol.
Again the reaction proceeds through the intermediate ketone. Acetyl chloride reacts with two moles of Ethylmagnesium bromide to furnish 3-methylpentanol. However, it is also possible to get the ketone in higher yields by using one mole of Grignard reagent. An analogous reaction of Grignard reagent is observed with carbon disulphide , CS 2 , to give alkanedithionic acid. Ethanedithionic acid can be prepared by reacting methylmagnesium chloride with carbon disulphide, CS 2.
Also in another analogous reaction with sulfur dioxide , SO 2 , an alkanesulphinic acid is formed. Methanesulphinic acid is formed when methylmagnesium chloride reacts with sulfur dioxide, SO 2. Whereas, alkane sulphonic acids are formed with sulfur trioxide , SO 3.
However, aldehydes are obtained when Grignard reagent are added with hydrogen cyanide , HCN followed by hydrolysis. Secondary butyl alcohol is obtained when 2-methyloxirane reacts with methylmagnesium iodide. The less substituted carbon of oxirane is substituted by the alkyl group of Grignard reagent.
Initially the Grignard reagent is added to the Weinreb amide, which further undergoes hydrolysis to furnish ketone. The addition of n-butylmagnesium bromide to the following Weinreb amide furnishes 3-heptanone. The alkylmagnesium chlorides or bromides are treated with Iodine to get corresponding alkyl iodides.
Indeed it is a side reaction that may be possible during the preparation of Grignard reagent. This reaction is catalyzed by Cuprous Cu I ions. These applications are depicted in the following reactions. A A Grignard reagent from the dihalobenzene adds to anthracene, followed by nucleophilic displacement of fluoride anion to form the product.
C A Grignard reagent from the dihalobenzene metalates the anthracene, and this nucleophile adds to the remaining fluorobenzene.
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